Hydroxylamine, O-ethyl- → HCID 136017205、化合物

HRID 2164363ノート

反応式

HRID 2164363 の反応式
[CH2:1]([NH:3][C:4](=[S:24])[NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]2[CH2:17][C:16](=[O:18])[C:15]([C:19](=O)[CH2:20][CH3:21])=[C:14]([OH:23])[CH2:13]2)=[CH:8][CH:7]=1)[CH3:2].[CH2:25]([O:27][NH2:28])[CH3:26]>C(Cl)(Cl)Cl>[CH2:25]([O:27][N:28]=[C:19]([C:15]1[C:16](=[O:18])[CH2:17][CH:12]([C:9]2[CH:8]=[CH:7][C:6]([NH:5][C:4]([NH:3][CH2:1][CH3:2])=[S:24])=[CH:11][CH:10]=2)[CH2:13][C:14]=1[OH:23])[CH2:20][CH3:21])[CH3:26]

参加物

4

反応物 2

HCID 69357Hydroxylamine, O-ethyl-HCID 178465509HCID 178465509、化合物

生成物 1

HCID 136017205HCID 136017205、化合物収率 88.9%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Into 10 ml of chloroform was dissolved 1.4 g of 5-{4-[3-(ethyl)thioureido]phenyl}-3-hydroxy-2-propionyl-2-cyclohexen-1-one and to the solution was added 1.0 g of ethoxyamine. The mixture was kept for 15 hours at room temperature and the reacting mixture was washed with a dilute hydrochloric acid solution and water. The solution was dried with anhydrous magnesium sulfate and the chloroform was distilled off from it under reduced pressure and 1.4 g of the desired compound was obtained. It was in the form of colorless crystals having a decomposition point of 116°-118° C.

後処理

  1. washthe reacting mixture was washed with a dilute hydrochloric acid solution and water
  2. dry with materialThe solution was dried with anhydrous magnesium sulfate
  3. distillationthe chloroform was distilled off from it under reduced pressure

出典と根拠

ORDレコード
ord-47597b6b219548cda2eb5fdcbacec4ac
出典データセット
uspto-grants-1985_03
特許番号
US04504305

反応ノート

読み込み中…