1-Methylpiperazine → Benzonitrile, 2-fluoro-6-(4-methyl-1-piperazinyl)-
反応式
F[C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[F:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:2]([N:15]2[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)[C:3]=1[C:4]#[N:5]参加物
3
実験手順
2,6-Difluorobenzonitrile is reacted with N-methyl piperazine following the procedure of Example 5. The reaction mixture is extracted with methylene chloride after addition of water. The methylene chloride is extracted with dilute HCl which is basified and extracted with methylene chloride. The resulting crude oil after evaporation is taken in ethanol and i-PrOH-HCl is added to give the title compound as the hydrochloride salt, 1.4 g m.p. 245°-247° C.
後処理
- extractionThe reaction mixture is extracted with methylene chloride
- additionafter addition of water
- extractionThe methylene chloride is extracted with dilute HCl which
- extractionextracted with methylene chloride
- customThe resulting crude oil after evaporation
- additioni-PrOH-HCl is added
出典と根拠
- ORDレコード
- ord-36441a7207f94b70bfa19aaa507cb8ea
- 出典データセット
- uspto-grants-1985_03
- 特許番号
- US04504660
反応ノート
読み込み中…