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Hydrochloric Acid → 2-Fluoro-6-(phenylamino)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | 2,6-Difluorobenzonitrile | HCID 74695 | — |
| 生成物 | 2-Fluoro-6-(phenylamino)benzonitrile | HCID 13469799 | — |
反応手順
A mixture of 2.8 g (20 mmol) of 2,6-difluorobenzonitrile in 20 ml of aniline is refluxed for 6 hrs. The mixture is poured into diluted HCl and the acid is extracted with methylene chloride. Evaporation gives the crude product which is chromatographed on silica gel (50% hexane--CH2Cl2) to give the title compound, m.p. 97°-99° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04504660 |
| 出典データセット | uspto-grants-1985_03 |
| ORD ID | ord-30c1ed890d374469b34a85c512485c68 |
| 出典メモ | uspto-grants-1985_03 |