反应详情

A mixture of 2.8 g (20 mmol) of 2,6-difluorobenzonitrile in 20 ml of aniline is refluxed for 6 hrs. The mixture is poured into diluted HCl and the acid is extracted with methylene chloride. Evaporation gives the crude product which is chromatographed on silica gel (50% hexane--CH2Cl2) to give the title compound, m.p. 97°-99° C.

1. temperatureis refluxed for 6 hrs
2. extractionthe acid is extracted with methylene chloride
3. customEvaporation
4. customgives the crude product which
5. customis chromatographed on silica gel (50% hexane--CH2Cl2)