Cyclohexanecarbonyl chloride → HCID 13423464、化合物
反応式
[NH2:1][C:2]1[O:3][N:4]=[C:5]2[C:10]=1[C:9](=[O:11])[N:8]([CH3:12])[C:7](=[O:13])[N:6]2[CH3:14].[CH:15]1([C:21](Cl)=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>N1C=CC=CC=1>[CH:15]1([C:21]([NH:1][C:2]2[O:3][N:4]=[C:5]3[C:10]=2[C:9](=[O:11])[N:8]([CH3:12])[C:7](=[O:13])[N:6]3[CH3:14])=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of 17.5 g of 3-amino-5,7-dimethylisoxazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione in 350 ml of pyridine, 26.2 g of cyclohexanecarbonyl chloride was added and the mixture was heated at 50° C. for 3 hours. The mixture was evaporated to dryness under reduced pressure and 200 ml of methanol was added to the residue. The resultant crystals were recrystallized twice from chloroform-methanol to afford 15.7 g of colorless needles, m.p. 210°-212° C.