Hydrochloric Acid → 6-Allyloxybenzothiazole-2-sulfonamide

HRID 2164615ノート

反応式

HRID 2164615 の反応式
CN(C)C=[N:4][S:5]([C:8]1[S:9][C:10]2[CH:16]=[C:15]([O:17][CH2:18][CH:19]=[CH2:20])[CH:14]=[CH:13][C:11]=2[N:12]=1)(=[O:7])=[O:6].[OH-].[Na+].O.Cl>CO>[CH2:18]([O:17][C:15]1[CH:14]=[CH:13][C:11]2[N:12]=[C:8]([S:5]([NH2:4])(=[O:7])=[O:6])[S:9][C:10]=2[CH:16]=1)[CH:19]=[CH2:20]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 53647804N,N-Dimethyl-N'-(6-allyloxybenzothiazole-2-sulfonyl)formamidine

生成物 1

HCID 134732046-Allyloxybenzothiazole-2-sulfonamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

A solution of product from Step B (0.45 gm, 1.4 mmol) in methanol (1.5 mL) was added to 2N sodium hydroxide (2 mL) and stirred at 40° C. for 1 hour. The reaction was poured into water, acidified (HCl), and the product extracted into ethyl acetate. The extract was dried (Na2SO4) and evaporated to give crude product. Upon trituration of this residue with methylene chloride, the product precipitated and was collected (0.18 gm) and shown to be identical with the product of Example 1.

後処理

  1. extractionthe product extracted into ethyl acetate
  2. dry with materialThe extract was dried (Na2SO4)
  3. customevaporated
  4. customto give crude product
  5. customUpon trituration of this residue with methylene chloride, the product precipitated
  6. customwas collected (0.18 gm)

出典と根拠

ORDレコード
ord-5581e90325654ed8a600846d876b58ed
出典データセット
uspto-grants-1985_03
特許番号
US04505923

反応ノート

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