Chlorine → 1-(5-Chloro-2,4-dihydroxy-3-propylphenyl)ethanone
反応式
[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([OH:11])[CH:5]=[CH:4][C:3]=1[C:12](=[O:14])[CH3:13].[Cl:15]Cl>C(Cl)(Cl)Cl>[Cl:15][C:5]1[C:6]([OH:11])=[C:7]([CH2:8][CH2:9][CH3:10])[C:2]([OH:1])=[C:3]([C:12](=[O:14])[CH3:13])[CH:4]=1参加物
4
実験手順
To a solution of 5.0 g (0.026 mol) of 1-(2,4-dihydroxy-3-propylphenyl)ethanone in 125 ml of chloroform was added 32.3 ml of (0.030 mol) 0.94M chlorine in chloroform dropwise at 25°. The mixture was stirred at 25° for 2.5 hours. The solvent was removed in vacuo and the residue was extracted with hot hexane. The hexane extract was boiled down to 100 ml and allowed to crystallize. Filtration gave 3.0 g, melting point 96°. (51% yield) of 1-(5-chloro-2,4-dihydroxy-3-propylphenyl)ethanone.
後処理
- customThe solvent was removed in vacuo
- extractionthe residue was extracted with hot hexane
- extractionThe hexane extract
- customto crystallize
- filtrationFiltration
- customgave 3.0 g, melting point 96°
出典と根拠
- ORDレコード
- ord-5438da4e9d554873aa15eea64d3849a9
- 出典データセット
- uspto-grants-1985_03
- 特許番号
- US04507498
反応ノート
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