Thionyl Chloride → 2-(1-Chloroethyl)-1,3-benzothiazole

HRID 2165073ノート

反応式

HRID 2165073 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10](O)[CH3:11].S(Cl)([Cl:15])=O>C(Cl)Cl>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]([Cl:15])[CH3:11]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 28306741-(1,3-Benzothiazol-2-yl)ethan-1-ol

生成物 1

HCID 109979582-(1-Chloroethyl)-1,3-benzothiazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1-(2-benzothiazolyl)ethanol (2.5 g) prepared according to J. Indian Chem. Soc., 566 (1974) in methylene chloride (50 ml) was added thionyl chloride (3.32 g) and the resulting solution stirred at room temperature for 1 hour. The solution was poured onto ice-water (100 ml) and the organic extract separated. This extract was washed with aqueous bicarbonate (10 ml of a 5% solution) and then with water (50 ml). The methylene chloride layer was dried over anhydrous magnesium sulfate and evaporated to a light yellow oil (2.08 g).

後処理

  1. additionThe solution was poured onto ice-water (100 ml)
  2. extractionthe organic extract
  3. customseparated
  4. washThis extract was washed with aqueous bicarbonate (10 ml of a 5% solution) and then with water (50 ml)
  5. dry with materialThe methylene chloride layer was dried over anhydrous magnesium sulfate
  6. customevaporated to a light yellow oil (2.08 g)

出典と根拠

ORDレコード
ord-b7ea343a2c8946b4a3ba7c2e6a332844
出典データセット
uspto-grants-1990_07
特許番号
US04939140

反応ノート

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