Benzaldehyde → 2-Propen-1-one,1-(5-methyl-2-thienyl)-3-phenyl-

HRID 2165128

反応式

HRID 2165128 の反応式
[OH-].[Na+].[C:3]([C:6]1[S:7][C:8]([CH3:11])=[CH:9][CH:10]=1)(=[O:5])[CH3:4].[CH:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.Cl>C(O)C>[CH3:11][C:8]1[S:7][C:6]([C:3](=[O:5])[CH:4]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:10][CH:9]=1

参加物

6

反応物 4

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 836552-Acetyl-5-methylthiophene

生成物 1

HCID 2386072-Propen-1-one,1-(5-methyl-2-thienyl)-3-phenyl-収率 67.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A stirred solution of 2.2 grams (0.055 mole) of sodium hydroxide in 20 ml of ethanol was cooled to 0° C. and a mixture of 4.0 grams (0.03 mole) of 2-acetyl-5-methylthiophene and 3.1 grams (0.03 mole) of benzaldehyde in 5 ml of ethanol was added dropwise. Upon completion of addition the reaction mixture was allowed to warm to ambient temperature where it stirred for 16 hours. The reaction mixture was poured into aqueous 1N hydrochloric acid and extracted with methylene chloride. The extract was dried with sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to yield 4.6 grams of 1-(5-methyl-2-thienyl)-3-phenyl-2-propen-1-one as a solid.

後処理

  1. additionwas added dropwise
  2. additionUpon completion of addition the reaction mixture
  3. extractionextracted with methylene chloride
  4. dry with materialThe extract was dried with sodium sulfate
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-70d25324e4b141e2a8305046095b2240
出典データセット
uspto-grants-1990_07
特許番号
US04939165

関連ノート

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