benzyl O-acetoacetyl-N-trifluoroacetyl-L-serinate → O-acetoacetyl-N-trifloroacetyl-L-serine

HRID 2165229ノート

反応式

HRID 2165229 の反応式
[C:1]([O:7][CH2:8][C@@H:9]([C:17]([O:19]CC1C=CC=CC=1)=[O:18])[NH:10][C:11](=[O:16])[C:12]([F:15])([F:14])[F:13])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]>[Pd].C(O)C>[C:1]([O:7][CH2:8][C@@H:9]([C:17]([OH:19])=[O:18])[NH:10][C:11](=[O:16])[C:12]([F:15])([F:14])[F:13])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]

参加物

4

反応物 1

HCID 53948101benzyl O-acetoacetyl-N-trifluoroacetyl-L-serinate

生成物 1

HCID 18640001O-acetoacetyl-N-trifloroacetyl-L-serine収率 95.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of benzyl O-acetoacetyl-N-trifluoroacetyl-L-serinate (320 mg) and 10% palladium on activated carbon (40 mg) in ethanol (10 ml) was hydrogenated under hydrogen at one atom for 20 minutes. The mixture was filtered with Celite (filter aid, trade mark, made by Nakarai Chemicals) and the filtrate was concentrated to give O-acetoacetyl-N-trifloroacetyl-L-serine (232 mg).

後処理

  1. filtrationThe mixture was filtered with Celite (filter aid, trade mark, made by Nakarai Chemicals)
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-4c02b58b79d64e88a2ff0a6eecbabd51
出典データセット
uspto-grants-1990_07
特許番号
US04939241

反応ノート

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