Sodium Hydroxide → HCID 18640048、化合物

HRID 2165250ノート

反応式

HRID 2165250 の反応式
C([C@@H]([C@H](C(O)=O)O)O)(O)=O.[NH2:11][C@H:12]1[CH2:16][CH2:15][NH:14][CH2:13]1.[OH-].[Na+].[Cl-:19].[K+].[Pt+2:21].[Cl-:22].[Cl-]>O>[Pt+2:21].[Cl:19][C@H:13]1[C@@H:12]([NH2:11])[CH2:16][CH2:15][N:14]1[Cl:22]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 86744074platinum (II) potassium chlorideHCID 86744075HCID 86744075、化合物

生成物 1

HCID 18640048HCID 18640048、化合物収率 63.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

(3S)-3-Aminopyrrolidine L(+)-tartrate (236 mg) prepared in Reference Example 1-(2) is dissolved in water (40 ml) and thereto is added sodium hydroxide (80 mg), and the mixture is stirred at room temperature. To the solution is added platinum (II) potassium chloride (415 mg), and the mixture is stirred at room temperature overnight. The precipitated solid is removed by filtration, and the filtrate is concentrated to dryness under reduced pressure. To the residue is added water (2 ml), and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3S)-3-aminopyrrolidine platinum (II) (221 mg) as pale yellow crystal.

後処理

  1. stirringthe mixture is stirred at room temperature overnight
  2. customThe precipitated solid is removed by filtration
  3. concentrationthe filtrate is concentrated to dryness under reduced pressure
  4. additionTo the residue is added water (2 ml)
  5. customthe resulting crystals are separated by filtration
  6. washwashed with water and acetone

出典と根拠

ORDレコード
ord-2f929b10abdf44e88701b4098c6aaa5a
出典データセット
uspto-grants-1990_07
特許番号
US04939256

反応ノート

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