Thionyl Chloride → 4-(6-Bromohexyloxy)benzoyl chloride

HRID 2165390ノート

反応式

HRID 2165390 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][CH:10]=1.S(Cl)([Cl:20])=O>>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([Cl:20])=[O:14])=[CH:11][CH:10]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 20064021HCID 20064021、化合物

生成物 1

HCID 200639874-(6-Bromohexyloxy)benzoyl chloride

実験手順

A mixture of 452 g of 4-(6-bromohexyloxy)benzoic acid and 1000 g of thionyl chloride was stirred at room temperature for about 20 hours. The reaction mixture was concentrated in vacuo and residual thionyl chloride removed by repeated addition of toluene and concentration in vacuo. The oily product comprising 4-(6-bromohexyloxy)benzoyl chloride (450 ml) was used directly in the next reaction.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo and residual thionyl chloride
  2. customremoved
  3. additionaddition of toluene and concentration in vacuo
  4. customThe oily product comprising 4-(6-bromohexyloxy)benzoyl chloride (450 ml) was used directly in the next reaction

出典と根拠

ORDレコード
ord-b57962b008124058811d7136199c57ea
出典データセット
uspto-grants-1990_07
特許番号
US04939267

反応ノート

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