Ammonia → Methyl 5-sulfamoyl-1,3-thiazole-4-carboxylate
反応式
Cl[S:2]([C:5]1[S:9][CH:8]=[N:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])=[O:3].[NH3:14]>O1CCCC1>[NH2:14][S:2]([C:5]1[S:9][CH:8]=[N:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])=[O:3]参加物
4
実験手順
A solution of 28.9 g of methyl 5-(chlorosulfonyl)-4-thiazolecarboxylate in 150 ml tetrahydrofuran was cooled to 0° and 6.6 ml of liquid ammonia was added dropwise at 0°-10°. The suspension was allowed to warm to ambient temperature and stirred 1 hour. The reaction mixture was filtered, the ammonium chloride washed with tetrahydrofuran, and the solvent evaporated from the filtrate. The residual solid was slurried in hexane, collected and dried to give 25.0 g of the title compound, m.p. 138°-140°. IR: 301 and 3.1μ (SO2NH2) and 5.8μ (C=O).
後処理
- filtrationThe reaction mixture was filtered
- washthe ammonium chloride washed with tetrahydrofuran
- customthe solvent evaporated from the filtrate
- customcollected
- customdried
出典と根拠
- ORDレコード
- ord-8ce6494fa38047f8a4eaa8c43d4d562a
- 出典データセット
- uspto-grants-1990_07
- 特許番号
- US04943312
反応ノート
読み込み中…