Glycine ethyl ester → HCID 59225865、化合物

HRID 216610

反応式

HRID 216610 の反応式
[Br:1][C:2]1[N:6]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([C:17]#[N:18])=[CH:9][CH:8]=2)[C:5]([S:19][CH2:20][C:21]([NH:23][CH2:24][C:25]([OH:27])=O)=[O:22])=[N:4][CH:3]=1.C([O:30][C:31](=[O:34])[CH2:32][NH2:33])C.BrC1N(C2C3C(=CC=CC=3)C(C#N)=CC=2)C(SCC(O)=O)=NC=1.NCC(NCC(OCC)=O)=O>>[Br:1][C:2]1[N:6]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([C:17]#[N:18])=[CH:9][CH:8]=2)[C:5]([S:19][CH2:20][C:21]([NH:23][CH2:24][C:25]([NH:33][CH2:32][C:31]([OH:34])=[O:30])=[O:27])=[O:22])=[N:4][CH:3]=1

参加物

5

反応物 4

HCID 12176Glycine ethyl esterHCID 124706Ethyl glycylglycinateHCID 46178862HCID 46178862、化合物HCID 59225886HCID 59225886、化合物

生成物 1

HCID 59225865HCID 59225865、化合物

実験手順

2-(2-(2-(5-bromo-1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)acetamido)acetamido)acetic acid is prepared via either of the two routes shown below. In the first, 2-(2-(5-bromo-1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)acetamido)acetic acid (see eg 3) is coupled with glycine ethyl ester and then hydrolyzed to the acid. In the second, 2-(5-bromo-1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)acetic acid (see eg 1) is coupled with NH2-Gly-Gly-OEt, which is then hydrolyzed to the acid.

出典と根拠

ORDレコード
ord-648304722cd14c4a87384e370a68add6
出典データセット
uspto-grants-2012_06
特許番号
US08193234B2

関連ノート

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