反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2([C:11]#N)[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.C(O)C[OH:15].[OH-:17].[K+].Cl>O>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2([C:11]([OH:15])=[O:17])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1参加物
6
反応条件
- 温度
- 140 °C
実験手順
1-(3-Bromophenyl)cyclopropanecarbonitrile (Reference compound 25-1, 5.0 g, 23 mmol) and ethylene glycol (20 mL) were added to a solution of potassium hydroxide (3.7 g, 66 mmol) in water (20 mL). The mixture was stirred at 140° C. for 4 hours. The reaction mixture was poured into a solution mixture of ice-water mL) and 6 N hydrochloric acid (50 mL). The precipitated solid was separated by filtration and dried under reduced pressure to give the title reference compound (4.7 q) as a brown solid (yield 87%).
後処理
- customThe precipitated solid was separated by filtration
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-e1535d90a9634d4cbaace9b50cfd045b
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08193237B2
関連ノート
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