ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Azobisisobutyronitrile → 3,6-anhydro-1,2-dideoxy-1-(diethoxyphosphinyl)-1,1-difluoro-4,5,7-tris-O-(phenylmethyl)-D-manno-heptitol

HRID 2166291
ノート
印刷プレビュー

反応式

HRID 2166291 の反応式
[CH2:1]([O:3][P:4]([O:41][CH2:42][CH3:43])([C:6]([F:40])([F:39])[C@@H:7]([C@H:9]1[O:29][C@H:28]([CH2:30][O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C@@H:19]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C@@H:10]1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)O)=[O:5])[CH3:2].C(OP(OCC)(C(F)(F)[C@@H](O)[C@H]1O[C@H](COCC2C=CC=CC=2)[C@@H](OCC2C=CC=CC=2)[C@@H]1OCC1C=CC=CC=1)=O)C.N(C(C)(C)C#N)=NC(C)(C)C#N>C1(C)C=CC=CC=1>[CH2:42]([O:41][P:4]([O:3][CH2:1][CH3:2])([C:6]([F:40])([F:39])[CH2:7][C@H:9]1[O:29][C@H:28]([CH2:30][O:31][CH2:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[C@@H:19]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C@@H:10]1[O:11][CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)=[O:5])[CH3:43]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 6547AzobisisobutyronitrileHCID 886089602,5-anhydro-7-deoxy-7-(diethoxyphosphinyl)-7,7-difluoro-1,3,4-tris-O-(phenylmethyl)-D-glycero-D-manno-heptitolHCID 886090023,6-anhydro-1-deoxy-1-(diethoxyphosphinyl)-1,1-difluoro-4,5,7-tris-O-(phenylmethyl)-D-glycero-D-galacto-heptitol

生成物 1

HCID 151171743,6-anhydro-1,2-dideoxy-1-(diethoxyphosphinyl)-1,1-difluoro-4,5,7-tris-O-(phenylmethyl)-D-manno-heptitol

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A 440 mg portion of a mixture of 3,6-anhydro-1-deoxy-1-(diethoxyphosphinyl)-1,1-difluoro-4,5,7-tris-O-(phenylmethyl)-D-glycero-D-galacto-heptitol, O-1H-imidazole-1-carbothioate and 2,5-anhydro-7-deoxy-7-(diethoxyphosphinyl)-7,7-difluoro-1,3,4-tris-O-(phenylmethyl)-D-glycero-D-manno-heptitol, O-1H-imidazole-1-carbothioate was dissolved in 12 ml of dry toluene, then treated with 900 μl of n-tributyl stannous hydride and a few crystals of 2,2'-azobisisobutyronitrile and heated in an oil bath under argon for 3 hours. The solution was cooled, then stored in a freezer and finally evaporated. The resulting oil was purified by chromatography giving the desired compound.

後処理

  1. temperatureThe solution was cooled
  2. customfinally evaporated
  3. customThe resulting oil was purified by chromatography

出典と根拠

ORDレコード
ord-951357c0d796462e9fdcf8ded0b1b03b
出典データセット
uspto-grants-1990_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04943629

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート