Potassium Carbonate → N-benzoyl-N'-t-butyl-N'-(ethoxycarbonyl)methylhydrazine

HRID 21663

反応式

HRID 21663 の反応式
[C:1]([NH:5][NH:6][C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[C:21]([O:24][CH2:25][CH2:26]Br)(=[O:23])[CH3:22]>CN(C)C=O.O.CCOCC>[C:7]([NH:6][N:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH2:22][C:21]([O:24][CH2:25][CH3:26])=[O:23])(=[O:14])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

参加物

7

反応物 3

HCID 11430Potassium CarbonateHCID 135641-Acetoxy-2-bromoethaneHCID 299436N'-tert-butylbenzohydrazide

生成物 1

HCID 15452013N-benzoyl-N'-t-butyl-N'-(ethoxycarbonyl)methylhydrazine収率 9.4%

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

実験手順

N'-t-butyl-N-benzoylhydrazine (2.0 g), powdered potassium carbonate (5 g) and bromoethyl acetate (1.6 g) were stirred in dimethylformamide (20 ml) at 60° C. for 14 hours. The reaction mixture was diluted with water and ether, and the organic layer was separated. The organic layer was washed several times with water, dried over magnesium sulfate and rotavapped to afford an oil. Chromatographic purification gave the pure oil product (0.25 g).

後処理

  1. customthe organic layer was separated
  2. washThe organic layer was washed several times with water
  3. dry with materialdried over magnesium sulfate
  4. customto afford an oil
  5. customChromatographic purification

出典と根拠

ORDレコード
ord-037e49102d464965acd586fc010b4458
出典データセット
uspto-grants-1995_06
特許番号
US05424333

関連ノート

読み込み中…