Potassium Carbonate → 4-Methoxymethyl-5-phenoxy-beta-carboline-3-carboxamidoxime

HRID 2166362ノート

反応式

HRID 2166362 の反応式
[C:1]([C:3]1[N:4]=[CH:5][C:6]2[NH:7][C:8]3[C:13]([C:14]=2[C:15]=1[CH2:16][O:17][CH3:18])=[C:12]([O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH:11]=[CH:10][CH:9]=3)#[N:2].Cl.[NH2:27][OH:28].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH3:18][O:17][CH2:16][C:15]1[C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][C:12]=3[O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[NH:7][C:6]=2[CH:5]=[N:4][C:3]=1[C:1](=[N:27][OH:28])[NH2:2]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 230394773-Cyano-4-methoxymethyl-5-phenoxy-beta-carboline

生成物 1

HCID 1362106304-Methoxymethyl-5-phenoxy-beta-carboline-3-carboxamidoxime

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 329 mg (0.001 mol) of 3-cyano-4-methoxymethyl-5-phenoxy-beta-carboline, 100 mg of hydroxylamine hydrochloride, 20 ml of ethanol (99%) and 0.52 ml of a 20% aqueous potassium carbonate solution is refluxed for 22 hours. The reaction mixture is filtered and the filtrate concentrated. The residue is mixed with 10 ml of water, the crystalline solid is filtered off and washed with water.

後処理

  1. temperatureis refluxed for 22 hours
  2. filtrationThe reaction mixture is filtered
  3. concentrationthe filtrate concentrated
  4. additionThe residue is mixed with 10 ml of water
  5. filtrationthe crystalline solid is filtered off
  6. washwashed with water

出典と根拠

ORDレコード
ord-6e26e0cbcdb34cd8a2d3ac2635446be7
出典データセット
uspto-grants-1990_07
特許番号
US04945090

反応ノート

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