Sodium Hydroxide → ST51001684
反応式
C([CH:6]1[CH:11]([CH2:12][CH:13]([S:15][CH2:16][CH3:17])[CH3:14])[CH2:10][C:9](=[O:18])[CH2:8][C:7]1=[O:19])(OCC)=O.[OH-].[Na+]>CO>[CH2:16]([S:15][CH:13]([CH3:14])[CH2:12][CH:11]1[CH2:6][C:7](=[O:19])[CH2:8][C:9](=[O:18])[CH2:10]1)[CH3:17]参加物
4
実験手順
The ester product of Example 1 (0.70 g, 2.4 mmole) was dissolved in 15 ml of methanol and 1 ml of 2N NaOH and heated to reflux for 21/2 hours. The mixture was maintained at room temperature overnight. Methanol was evaporated, and the residue partitioned between about 30 ml of toluene and about 30 ml of aqueous HCl. The toluene extract was dried over sodium sulfate and evaporated to give 0.35 g (66.8%) of product as a yellow solid which was identical with an authentic sample. This target product was further identified by NMR.
後処理
- temperatureto reflux for 21/2 hours
- customMethanol was evaporated
- customthe residue partitioned between about 30 ml of toluene and about 30 ml of aqueous HCl
- extractionThe toluene extract
- dry with materialwas dried over sodium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-890255096db4480e94077fac6deb025a
- 出典データセット
- uspto-grants-1990_07
- 特許番号
- US04945178
反応ノート
読み込み中…