Allyl bromide → 3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-1-N-(2-propenyl)piperidine

HRID 2166627ノート

反応式

HRID 2166627 の反応式
CC(C1C=CC(C2CCCNC2)=C(O)C=1)(C)CCCCCC.C(=O)([O-])[O-].[K+].[K+].C(Br)C=C.[CH3:33][C:34]([C:42]1[CH:47]=[CH:46][C:45]([CH:48]2[CH2:53][CH2:52][CH2:51][N:50]([CH2:54][CH:55]=[CH2:56])[CH2:49]2)=[C:44]([O:57]CC=C)[CH:43]=1)([CH3:41])[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]>C(O)C>[CH3:41][C:34]([C:42]1[CH:47]=[CH:46][C:45]([CH:48]2[CH2:53][CH2:52][CH2:51][N:50]([CH2:54][CH:55]=[CH2:56])[CH2:49]2)=[C:44]([OH:57])[CH:43]=1)([CH3:33])[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]

参加物

6

反応物 4

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 155715583-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]piperidineHCID 204997773-[4-(1,1-dimethylheptyl)-2-allyloxyphenyl]-1-N-(2-propenyl)-piperidine

生成物 1

HCID 204997903-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-1-N-(2-propenyl)piperidine収率 40%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 900 mg. (2.97 mmoles) of 3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]piperidine, 481 mg. (3.48 mmoles) of anhydrous potassium carbonate and 359 mg. (2.97 mmoles) of allyl bromide in 20 ml. of ethanol is heated at reflux for 23 hours. The reaction mixture is concentrated under reduced pressure and the residue dissolved in 250 ml. of saturated sodium bicarbonate and 200 ml. of dichloromethane. The organic extract is washed once with 100 ml. of saturated sodium chloride, dried over magnesium sulfate and evaporated under reduced pressure to an oil. The oil is purified via column chromatography on 125 g. of silica gel eluted with 25% cyclohexane-ether to yield 172 mg. (15%) of 3-[4-(1,1-dimethylheptyl)-2-allyloxyphenyl]-1-N-(2-propenyl)-piperidine as an oil and 411 mg. (40%) of the title compound as an oil.

後処理

  1. additionA mixture of 900 mg
  2. temperatureat reflux for 23 hours
  3. concentrationThe reaction mixture is concentrated under reduced pressure
  4. dissolutionthe residue dissolved in 250 ml
  5. extractionThe organic extract
  6. washis washed once with 100 ml
  7. dry with materialof saturated sodium chloride, dried over magnesium sulfate
  8. customevaporated under reduced pressure to an oil
  9. customThe oil is purified via column chromatography on 125 g
  10. washof silica gel eluted with 25% cyclohexane-ether
  11. customto yield 172 mg

出典と根拠

ORDレコード
ord-13fb1860210d41ebb32bb147f1a5a9d4
出典データセット
uspto-grants-1983_06
特許番号
US04387229

反応ノート

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