Methanol → methyl N-(3,4-dichlorophenyl)carbamate

HRID 2166656

反応式

HRID 2166656 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[Cl:9])[NH2:5].[C:10](=[O:14])([O:12][CH3:13])N.ClC1C=C(NC(NC2C=CC(Cl)=C(Cl)C=2)=O)C=CC=1Cl.CO>ClC1C=CC=CC=1>[CH3:13][O:12][C:10](=[O:14])[NH:5][C:4]1[CH:6]=[CH:7][C:8]([Cl:9])=[C:2]([Cl:1])[CH:3]=1

参加物

6

反応物 4

HCID 887MethanolHCID 72573,4-DichloroanilineHCID 11722Methyl CarbamateHCID 957833,3',4,4'-Tetrachlorocarbanilide

生成物 1

HCID 15969methyl N-(3,4-dichlorophenyl)carbamate

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

実験手順

648 g of 3,4-dichloroaniline, 360 g methyl carbamate, 280 g N,N'-bis-(3,4-dichlorophenyl)-urea, 385 g methanol and 1600 g chlorobenzene were reacted in the apparatus described in Example 1 for 6.0 hours at 200° C. After the apparatus had cooled and the pressure had been reduced, the reaction mixture was removed, filtered and analyzed by high pressure liquid chromatography (HPLC). A yield of 990 g (80% of the theoretical yield) of N-(3,4-dichlorophenyl)-carbamic acid-methyl ester was obtained.

後処理

  1. temperatureAfter the apparatus had cooled
  2. customthe reaction mixture was removed
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-b07ef4cb5ee64059871f950383525712
出典データセット
uspto-grants-1983_06
特許番号
US04388238

関連ノート

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