Benzene → 2-Bromo-1-(bromomethyl)-4-(trifluoromethyl)benzene

HRID 2167126ノート

反応式

HRID 2167126 の反応式
C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C1C=CC=CC=1.[Br:25][C:26]1[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][C:27]=1[CH3:36].C1C(=O)N([Br:44])C(=O)C1>CCOC(C)=O>[Br:25][C:26]1[CH:31]=[C:30]([C:32]([F:33])([F:34])[F:35])[CH:29]=[CH:28][C:27]=1[CH2:36][Br:44]

参加物

6

反応物 4

HCID 241BenzeneHCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 27793762-Bromo-1-methyl-4-(trifluoromethyl)benzene

生成物 1

HCID 149499362-Bromo-1-(bromomethyl)-4-(trifluoromethyl)benzene

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Solid benzoyl peroxide (1.5 g, 6.3 mmol) was added to a benzene solution (200 mL) of 2-bromo-1-methyl-4-(trifluoromethyl)benzene (10.0 g, 41.8 mmol) and NBS (8.2 g, 46.0 mmol) and the resulting mixture was refluxed. After 16 h the resulting mixture was cooled, diluted with EtOAc, washed with water and brine, dried (Na2SO4), and dry packed onto silica gel. Column chromatography yielded the title compound.

後処理

  1. temperaturethe resulting mixture was refluxed
  2. temperatureAfter 16 h the resulting mixture was cooled
  3. washwashed with water and brine
  4. dry with materialdried (Na2SO4)
  5. customdry

出典と根拠

ORDレコード
ord-0d199021d8924a9c972e133f47df041a
出典データセット
uspto-grants-2015_06
特許番号
US09045389B2

反応ノート

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