Dimethylformamide → 2,6-Dichloro-4-(trifluoromethyl)benzaldehyde
反応式
[Li]CCCC.[Cl:6][C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[C:9]([Cl:17])[CH:8]=1.CN([CH:21]=[O:22])C>C1COCC1>[Cl:6][C:7]1[CH:12]=[C:11]([C:13]([F:14])([F:15])[F:16])[CH:10]=[C:9]([Cl:17])[C:8]=1[CH:21]=[O:22]参加物
5
反応条件
- 温度
- 0 °C
実験手順
A 2M n-BuLi solution (5.8 mL, 11.6 mmol) was added to a −78° C. THF solution (60 mL) of 1,3-dichloro-5-(trifluoromethyl)benzene (2.5 g, 11.6 mmol). After 45 min neat DMF (0.39 mL, 5.0 mmol) was added, and the resulting solution was allowed to warm to 0° C. gradually, quenched with NH4Cl solution, and extracted with diethyl ether. The combined extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.
後処理
- customquenched with NH4Cl solution
- extractionextracted with diethyl ether
- dry with materialThe combined extracts were dried (Na2SO4)
- concentrationconcentrated
- custompurified via column chromatography
出典と根拠
- ORDレコード
- ord-a3100613125448ef867ddb0910b71a8e
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09045389B2
反応ノート
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