Hydrochloric Acid → 1-Oxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
反応式
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13]C)=[O:12])=[CH:8][CH:9]=2)[CH2:4][NH:3]1.[OH-].[Na+].Cl>CO>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=2)[CH2:4][NH:3]1参加物
5
実験手順
To a methanol (5.0 mL) solution of methyl 1-oxo-2,3-dihydro-1H-isoindole-5-carboxylate (0.33 g), a 1 mol/L aqueous sodium hydroxide solution (4.3 mL) was added, and the resultant was stirred at room temperature for 24 hours. A 1 mol/L aqueous hydrochloric acid solution was added to the reaction solution. The deposited solid was collected by filtration and dried to obtain the title compound (0.29 g) as a white solid.
後処理
- filtrationThe deposited solid was collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-5cdb461f8b6a49b8898053ed5ca8cf38
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09045466B2
反応ノート
読み込み中…