Hydrochloric Acid → HCID 11845779、化合物
反応式
[N:1]1[C:2]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=12.[ClH:15]>CCO.[Pd]>[ClH:15].[N:1]1[C:2]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3][N:4]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=12参加物
5
実験手順
10% Pd/C (40 mg) was added to a solution of ethyl imidazo[1,2-a]pyrazine-2-carboxylate (410 mg, 2.15 mmol) and conc.HCl (0.5 mL) in EtOH (9.5 mL) and stirring was continued under a hydrogen atmosphere for 16 h. The reaction mixture was filtered over a celite bed and the filtrate was concentrated under reduced pressure to afford the crude product, which was purified by washing with diethyl ether and dried to afford 400 mg of the title compound as a yellow hygroscopic solid.
後処理
- filtrationThe reaction mixture was filtered over a celite bed
- concentrationthe filtrate was concentrated under reduced pressure
- customto afford the crude product, which
- customwas purified
- washby washing with diethyl ether
- customdried
出典と根拠
- ORDレコード
- ord-d14bb2a2bfff4b45843e094fdc4902f4
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09045479B2
反応ノート
読み込み中…