Hydrazine hydrate (1:1) → 6-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

HRID 2167797

反応式

HRID 2167797 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[N:8][CH:9]=1)([O-])=O.O.NN>[Ni].C(O)C.CO>[N:10]1([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH:14]=[N:13][CH:12]=[N:11]1

参加物

6

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

生成物 1

HCID 167723276-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 702Ethanol溶媒HCID 887Methanol溶媒

実験手順

Raney nickel (0.650 g) was added to a solution of 5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine (3.2 g, 16.7 mmol) in a mixture of ethanol and methanol (1:1) (150 mL) followed by the addition of Hydrazine hydrate (2.51 g, 50.2 mmol) and stirring was continued at 25° C. 1 hr. The reaction mixture was filtered over celite bed and washed with methanol. The filtrate and the washings were concentrated under reduced pressure to afford title compound as pale brown liquid. MS (ESI): m/z 162.1 (M+H).

後処理

  1. customwas continued at 25° C
  2. custom1 hr
  3. filtrationThe reaction mixture was filtered over celite bed
  4. washwashed with methanol
  5. concentrationThe filtrate and the washings were concentrated under reduced pressure

出典と根拠

ORDレコード
ord-144c7b6f515b41598b22ac4f6e0f72af
出典データセット
uspto-grants-2015_06
特許番号
US09045479B2

関連ノート

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