N-bromobutanimide → Methyl 5-bromo-1H-pyrrole-2-carboxylate
反応式
COCCCC[N:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[C:12]([O:14][CH3:15])=[O:13].[Br:16]N1C(=O)CCC1=O>ClCCl>[Br:16][C:11]1[NH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:10]=1参加物
4
実験手順
Methyl 1-(4-methoxybutyl)-1H-pyrrole-2-carboxylate (4.5 g) was dissolved in dichloromethane (30 ml), N-bromosuccinimide (4.0 g) was added and the mixture was stirred for 1 hr. The reaction mixture was washed successively with water and brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography, and a fraction eluted with ethyl acetate-hexane (1:4) was concentrated under reduced pressure to give the object product (2.2 g).
後処理
- washThe reaction mixture was washed successively with water and brine
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was evaporated under reduced pressure
- washa fraction eluted with ethyl acetate-hexane (1:4)
- concentrationwas concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-05aed2484370403183692ffd0c3f08b5
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09045436B2
反応ノート
読み込み中…