化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 4-bromo-2-(bromomethyl)benzoate → 5-Bromo-2-methyl-2,3-dihydro-1H-isoindol-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-bromo-2-(bromomethyl)benzoate | HCID 22031079 | — |
| 反応物 | Monomethylamine methanol | HCID 57454252 | — |
| 生成物 | 5-Bromo-2-methyl-2,3-dihydro-1H-isoindol-1-one | HCID 23158169 | — |
反応手順
A solution of methyl 4-bromo-2-(bromomethyl)benzoate (410 mmol) in MeNH2/MeOH (1500 mL) was heated to reflux and stirred for 18 h. The reaction mixture was concentrated and the residue was purified by chromatography on silica eluting with petroleum ether/ethyl acetate (6:1 to 3:1) to afford the sub-titled compound (48.5 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08193239B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-1ee68ce3184b4df29e51592a33f34921 |
| 出典メモ | uspto-grants-2012_06 |