Hydrochloric Acid → 4-(1-Ethoxyethyl)benzoic acid

HRID 2170473ノート

反応式

HRID 2170473 の反応式
[CH2:1]([O:3][CH:4]([C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][CH:7]=1)[CH3:5])[CH3:2].[OH-].[Li+].Cl>CO.O>[CH2:1]([O:3][CH:4]([C:6]1[CH:7]=[CH:8][C:9]([C:10]([OH:12])=[O:11])=[CH:14][CH:15]=1)[CH3:5])[CH3:2]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 89580551Methyl 4-(1-ethoxyethyl)benzoate

生成物 1

HCID 189137424-(1-Ethoxyethyl)benzoic acid収率 93.5%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To the solution of methyl 4-(1-ethoxyethyl)benzoate (191 mg, 0.92 mmol) in methanol and water (50 mL/10 mL) was added lithium hydroxide (100 mg, 4.2 mmol), the solution was stirred at room temperature for 12 hours. Then the solution was acidified by hydrogen chloride (1 N/mol) pH to 6, extracted with dichloromethane (80 mL*3), evaporated the solvent to give 4-(1-ethoxyethyl)benzoic acid (167 mg, 93%).

後処理

  1. extractionto 6, extracted with dichloromethane (80 mL*3)
  2. customevaporated the solvent

出典と根拠

ORDレコード
ord-14fc3b6f7a22478282c172e23675d490
出典データセット
uspto-grants-2015_06
特許番号
US09051269B2

反応ノート

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