Borane → HCID 13142463、化合物
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:13])[CH2:9][C:10](O)=[O:11])=[CH:4][CH:3]=1.B>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH3:13])[CH2:9][CH2:10][OH:11])=[CH:6][CH:7]=1参加物
4
実験手順
To the solution of 3-(4-bromophenyl)butanoic acid (1 g, 4.1 mmol) in tetrahydrofuran (100 mL) was added borane in tetrahydrofuran (8 mL, 1 mol/L), the solution was stirred at reflux for 2 hours, then the solution was concentrated and purified by column chromatography (silica gel, Petroleum ether/ethyl acetate=20:1) to give 3-(4-bromophenyl)butan-1-ol (791 mg, 84.6%).
後処理
- temperatureat reflux for 2 hours
- concentrationthe solution was concentrated
- custompurified by column chromatography (silica gel, Petroleum ether/ethyl acetate=20:1)
出典と根拠
- ORDレコード
- ord-2aa00d45c5614373ab792fe55357b590
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09051269B2
反応ノート
読み込み中…