Morpholine → HCID 71075337、化合物

HRID 2170627ノート

反応式

HRID 2170627 の反応式
[CH3:1][O:2][C:3](=[O:30])[CH2:4][O:5][C:6]1[CH:29]=[CH:28][C:9]([CH2:10][N:11]2[C:19]3[C:14](=[CH:15][C:16]([C:20]([O:22]CC=C)=[O:21])=[CH:17][CH:18]=3)[C:13]([CH3:26])=[C:12]2[CH3:27])=[CH:8][CH:7]=1.N1CCOCC1>C1COCC1.C(OCC)(=O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:1][O:2][C:3](=[O:30])[CH2:4][O:5][C:6]1[CH:29]=[CH:28][C:9]([CH2:10][N:11]2[C:19]3[C:14](=[CH:15][C:16]([C:20]([OH:22])=[O:21])=[CH:17][CH:18]=3)[C:13]([CH3:26])=[C:12]2[CH3:27])=[CH:8][CH:7]=1

参加物

6

反応物 2

HCID 8083MorpholineHCID 86674581HCID 86674581、化合物

生成物 1

HCID 71075337HCID 71075337、化合物

試薬・触媒・溶媒 3

HCID 178418397HCID 178418397、化合物触媒HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of the allyl 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylate (536 mg, 1.3 mmol) and morpholine (1.14 mL, 13.2 mmol) in anhydrous THF was degassed with argon. Then Pd(PPh3)4 (152 mg, 0.13 mmol) was added and the reaction stirred under argon protection for 1.5 h. The reaction mixture was diluted with ethyl acetate, washed with brine, concentrated. The title compound was precipitated in ethyl ether as a beige powder (430 mg, 89%). ESI-MS (m/z): 368 [M+H]+.

後処理

  1. washwashed with brine
  2. concentrationconcentrated
  3. customThe title compound was precipitated in ethyl ether as a beige powder (430 mg, 89%)

出典と根拠

ORDレコード
ord-06f705ca21e14c64ac320f1da5723ee9
出典データセット
uspto-grants-2015_06
特許番号
US09051265B2

反応ノート

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