Diisopropylethylamine → HCID 71075406、化合物

HRID 2170628ノート

反応式

HRID 2170628 の反応式
[CH3:1][O:2][C:3](=[O:27])[CH2:4][O:5][C:6]1[CH:26]=[CH:25][C:9]([CH2:10][N:11]2[C:19]3[C:14](=[CH:15][C:16]([C:20](O)=[O:21])=[CH:17][CH:18]=3)[C:13]([CH3:23])=[C:12]2[CH3:24])=[CH:8][CH:7]=1.Cl.[CH:29]1([C:32]2[CH:33]=[C:34]([C@@H:38]([NH2:40])[CH3:39])[CH:35]=[CH:36][CH:37]=2)[CH2:31][CH2:30]1.CCN(C(C)C)C(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>C(Cl)Cl.C(OCC)(=O)C>[CH:29]1([C:32]2[CH:33]=[C:34]([C@@H:38]([NH:40][C:20]([C:16]3[CH:15]=[C:14]4[C:19](=[CH:18][CH:17]=3)[N:11]([CH2:10][C:9]3[CH:8]=[CH:7][C:6]([O:5][CH2:4][C:3]([O:2][CH3:1])=[O:27])=[CH:26][CH:25]=3)[C:12]([CH3:24])=[C:13]4[CH3:23])=[O:21])[CH3:39])[CH:35]=[CH:36][CH:37]=2)[CH2:31][CH2:30]1

参加物

7

反応物 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 71075337HCID 71075337、化合物HCID 86674582HCID 86674582、化合物

生成物 1

HCID 71075406HCID 71075406、化合物収率 102.1%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid (50 mg, 0.14 mmol) in DCM (1 mL) was added the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride (28 mg), DIEA (73 μL) and HATU (53 mg). The reaction mixture was allowed to stir at rt for 30 min, and then was diluted by ethyl acetate. The resulting mixture was washed with a 0.5 N HCl solution, a saturated solution of NaHCO3, and brine, dried on MgSO4, and concentrated to afford a yellow oil (73 mg) which was directly used without further purification. ESI-MS (m/z): 497 [M+H]+

後処理

  1. washThe resulting mixture was washed with a 0.5 N HCl solution
  2. dry with materiala saturated solution of NaHCO3, and brine, dried on MgSO4
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-635ec30f66e24bb89e15eace0a5c1027
出典データセット
uspto-grants-2015_06
特許番号
US09051265B2

反応ノート

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