Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 71075200、化合物

HRID 2170659ノート

反応式

HRID 2170659 の反応式
[Cl:1][C:2]1[CH:22]=[CH:21][C:20]([O:23][C@@H:24]([CH3:29])[C:25]([O:27][CH3:28])=[O:26])=[CH:19][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14](O)=[O:15])=[CH:11][CH:12]=2)[C:7]([CH3:17])=[C:6]1[CH3:18].Cl.[CH:31]([C:34]1[CH:35]=[C:36]([C@@H:40]([NH2:42])[CH3:41])[CH:37]=[CH:38][CH:39]=1)([CH3:33])[CH3:32].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CN(C=O)C.CCN(C(C)C)C(C)C>[Cl:1][C:2]1[CH:22]=[CH:21][C:20]([O:23][C@@H:24]([CH3:29])[C:25]([O:27][CH3:28])=[O:26])=[CH:19][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14](=[O:15])[NH:42][C@H:40]([C:36]3[CH:37]=[CH:38][CH:39]=[C:34]([CH:31]([CH3:33])[CH3:32])[CH:35]=3)[CH3:41])=[CH:11][CH:12]=2)[C:7]([CH3:17])=[C:6]1[CH3:18]

参加物

6

反応物 3

HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 71075618HCID 71075618、化合物HCID 86674569HCID 86674569、化合物

生成物 1

HCID 71075200HCID 71075200、化合物

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 81531Diisopropylethylamine溶媒

実験手順

The (S)-1-(2-chloro-5-((1-methoxy-1-oxopropan-2-yl)oxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid (71 mg, 0.17 mmol), the (S)-1-(3-isopropylphenyl)ethanamine hydrochloride (53 mg, 0.27 mmol) and HATU (88 mg, 0.23 mmol) were dissolved in DMF (3 mL) and DIEA (0.15 mL). It was stirred for 15 h. The solution was filtered and purified by preparative HPLC.

後処理

  1. filtrationThe solution was filtered
  2. custompurified by preparative HPLC

出典と根拠

ORDレコード
ord-b2ff93f7ab094795a37e491c605e7116
出典データセット
uspto-grants-2015_06
特許番号
US09051265B2

反応ノート

読み込み中…