Morpholine → HCID 71075610、化合物

HRID 2170700ノート

反応式

HRID 2170700 の反応式
[C:1]([C:3]([C:6]1[CH:7]=[C:8]([CH:27]=[CH:28][CH:29]=1)[CH2:9][N:10]1[C:18]2[C:13](=[CH:14][C:15]([C:19]([O:21]CC=C)=[O:20])=[CH:16][CH:17]=2)[C:12]([CH3:25])=[C:11]1[CH3:26])([CH3:5])[CH3:4])#[N:2].N1CCOCC1>C1COCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:1]([C:3]([C:6]1[CH:7]=[C:8]([CH:27]=[CH:28][CH:29]=1)[CH2:9][N:10]1[C:18]2[C:13](=[CH:14][C:15]([C:19]([OH:21])=[O:20])=[CH:16][CH:17]=2)[C:12]([CH3:25])=[C:11]1[CH3:26])([CH3:5])[CH3:4])#[N:2]

参加物

5

反応物 2

HCID 8083MorpholineHCID 86674589HCID 86674589、化合物

生成物 1

HCID 71075610HCID 71075610、化合物

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

The mixture of allyl 1-(3-(2-cyanopropan-2-yl)benzyl)-2,3-dimethyl-1H-indole-5-carboxylate (0.688 g, 1.78 mmol) and morpholine (1.6 mL, 17.8 mmol) in THF (5 mL) was degassed and then Pd(PPh3)4 (0.21 g, 0.18 mmol) was added. The mixture was stirred at room temperature for 1 h. The solvent was removed and the residue was dissolved in Methanol and acidified to pH4. The solvent was removed and the residue was purified by silica gel to obtain the title compound. ESI-MS (m/z): 347 [M+H]+.

後処理

  1. customwas degassed
  2. customThe solvent was removed
  3. dissolutionthe residue was dissolved in Methanol
  4. customThe solvent was removed
  5. customthe residue was purified by silica gel

出典と根拠

ORDレコード
ord-44b3877c85414afba2a9b233191fd665
出典データセット
uspto-grants-2015_06
特許番号
US09051265B2

反応ノート

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