HCID 66926091、化合物 → HCID 66926106、化合物

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH3:13])[N:10]([CH:14]3[C:18](=[O:19])/[C:17](=[CH:20]\[C:21]4[CH:26]=[CH:25][C:24]([F:27])=[CH:23][N:22]=4)/[CH2:16][C:15]3=[O:28])[N:9]=2)=[CH:4][CH:3]=1.[H][H]>CO.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH3:13])[N:10]([CH:14]3[C:18](=[O:19])[CH:17]([CH2:20][C:21]4[CH:26]=[CH:25][C:24]([F:27])=[CH:23][N:22]=4)[CH2:16][C:15]3=[O:28])[N:9]=2)=[CH:4][CH:3]=1

参加物

実験手順

To a solution of 2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-[1-(5-fluoro-pyridin-2-yl)-meth-(Z)-ylidene]-cyclopentane-1,3-dione (17 mg, 0.04 mmol) in methanol (0.4 ml) was added 5% palladium on activated charcoal (2 mg) and the reaction stirred for 6 hours under 1.5 bar of hydrogen. The solution was then filtered through a pad of Celite, washed with methanol (10 ml) and concentrated in vacuo to give a white solid, which was purified by column chromatography using DCM:EtOAc:AcOH (9:1:0.01%) to (3:7:0.01%) to give 2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)-cyclopentane-1,3-dione (15.7 mg).