Hydrochloric Acid → MFCD18873289

HRID 2170850ノート

反応式

HRID 2170850 の反応式
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([O:16]C)=[O:15])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1.[OH-].[Na+].Cl>CO>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([OH:16])=[O:15])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 671694841H-Indole-5-carboxylic acid, 1-(2-methoxyethyl)-, methyl ester

生成物 1

HCID 63750378MFCD18873289収率 95%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

A mixture of methyl 1-(2-methoxyethyl)-1H-indole-5-carboxylate (132 mg, 0.57 mmol, Step-1), 2M aqueous sodium hydroxide solution (2 mL), and methanol (2 mL) was stirred at 60° C. for 2 hours. The mixture was acidified with 2M aqueous hydrochloric acid solution, and the organic solvent was concentrated under reduced pressure. The precipitate was collected by filtration and dried to give 118 mg (95%) of the title compound as a white solid.

後処理

  1. concentrationthe organic solvent was concentrated under reduced pressure
  2. filtrationThe precipitate was collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-9d1f213d501747d5a0db55da64284643
出典データセット
uspto-grants-2015_06
特許番号
US09051296B2

反応ノート

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