Tributylamine → UTP tributylamine

HRID 217096

反応式

HRID 217096 の反応式
[CH:1]1[C:7](=[O:8])[NH:6][C:4](=[O:5])[N:3]([CH:9]2[O:13][CH:12]([CH2:14][O:15][P:16]([O:19][P:20]([O:23][P:24]([O-:27])([OH:26])=[O:25])([O-:22])=[O:21])([O-:18])=[O:17])[CH:11]([OH:28])[CH:10]2[OH:29])[CH:2]=1.[Na+].[Na+].[Na+].[CH2:33]([N:37]([CH2:42][CH2:43][CH2:44][CH3:45])[CH2:38][CH2:39][CH2:40][CH3:41])[CH2:34][CH2:35][CH3:36]>O>[CH:1]1[C:7](=[O:8])[NH:6][C:4](=[O:5])[N:3]([C@@H:9]2[O:13][C@H:12]([CH2:14][O:15][P:16]([O:19][P:20]([O:23][P:24]([OH:26])([OH:27])=[O:25])([OH:22])=[O:21])([OH:18])=[O:17])[C@@H:11]([OH:28])[C@H:10]2[OH:29])[CH:2]=1.[CH2:42]([N:37]([CH2:33][CH2:34][CH2:35][CH3:36])[CH2:38][CH2:39][CH2:40][CH3:41])[CH2:43][CH2:44][CH3:45]

参加物

4

反応物 2

HCID 7622TributylamineHCID 3563637CID 3563637

生成物 1

HCID 86638271UTP tributylamine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

UTP trisodium salt (1.00 g, 1.82 mmol) was dissolved in deionized water (13 mL), and the solution was caused to pass through a strong cation-exchange column (PK 216, proton-type, 10 cc). The eluate was mixed with a column wash solution, and the mixture was neutralized with tributylamine (1.75 mL, 7.35 mmol). The resultant solution was concentrated under reduced pressure, and the residue was co-boiled four times with dioxane (10 mL). The residue was dissolved in dimethylformamide (10 mL), to thereby yield a 0.133 M dimethylformamide solution of UTP tributylamine salt.

後処理

  1. additionThe eluate was mixed with a column
  2. washwash solution
  3. concentrationThe resultant solution was concentrated under reduced pressure
  4. dissolutionThe residue was dissolved in dimethylformamide (10 mL)

出典と根拠

ORDレコード
ord-8ffcaae619e04ce09586380e6fad09d9
出典データセット
uspto-grants-2012_06
特許番号
US08193338B2

関連ノート

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