Butyryl chloride → HCID 71279602、化合物

HRID 2171025ノート

反応式

HRID 2171025 の反応式
[NH2:1][CH2:2][C:3]1([CH2:6][O:7][C:8]2[C:13]([O:14][CH3:15])=[C:12]([O:16][CH3:17])[CH:11]=[CH:10][C:9]=2[C:18]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=2[CH2:20][CH2:21][C:22]3=[O:27])[CH2:5][CH2:4]1.C(N(C(C)C)CC)(C)C.[C:37](Cl)(=[O:41])[CH2:38][CH2:39][CH3:40]>ClCCl>[CH3:15][O:14][C:13]1[C:12]([O:16][CH3:17])=[CH:11][CH:10]=[C:9]([C:18]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=2[CH2:20][CH2:21][C:22]3=[O:27])[C:8]=1[O:7][CH2:6][C:3]1([CH2:2][NH:1][C:37](=[O:41])[CH2:38][CH2:39][CH3:40])[CH2:4][CH2:5]1

参加物

5

反応物 3

HCID 8855Butyryl chlorideHCID 81531DiisopropylethylamineHCID 71279377HCID 71279377、化合物2 回

生成物 1

HCID 71279602HCID 71279602、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirring solution of 4-[2-(1-Aminomethyl-cyclopropylmethoxy)-3,4-dimethoxy-phenyl]-indan-1-one (Compound 182) (100 mg, 0.272 mmol) in dichloromethane (10 mL), were added diisopropylethylamine (0.034 g, 0.272 mmol) and butyryl chloride (29 mg, 0.272 mmol) and the resultant reaction mixture was subjected to the conditions used in the preparation of compound 183 to afford the title compound as a solid.

後処理

  1. customthe resultant reaction mixture

出典と根拠

ORDレコード
ord-43893b578d1e44e2b78058e9986427ff
出典データセット
uspto-grants-2015_06
特許番号
US09051290B2

反応ノート

読み込み中…