Potassium Carbonate → 4-((6-Bromo-3-(difluoromethoxy)-2-methoxyphenoxy)methyl)benzamide

HRID 2171077ノート

反応式

HRID 2171077 の反応式
[Br:1][C:2]1[C:7]([OH:8])=[C:6]([O:9][CH3:10])[C:5]([O:11][CH:12]([F:14])[F:13])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=1>C(#N)C>[Br:1][C:2]1[C:7]([O:8][CH2:22][C:23]2[CH:31]=[CH:30][C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=2)=[C:6]([O:9][CH3:10])[C:5]([O:11][CH:12]([F:13])[F:14])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 5842164-(Bromomethyl)benzamideHCID 674670406-Bromo-3-(difluoromethoxy)-2-methoxyphenol

生成物 1

HCID 674639064-((6-Bromo-3-(difluoromethoxy)-2-methoxyphenoxy)methyl)benzamide収率 67%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
80 °C

実験手順

To a stirring solution of 6-bromo-3-(difluoromethoxy)-2-methoxyphenol (1.0 g, 3.71 mmol) in acetonitrile (10 mL), was added potassium carbonate (1.53 g, 11.08 mmol) and followed by 4-(bromomethyl)benzamide (795 mg, 3.71 mmol) and the resultant reaction mixture was heated to 80° C. for 16 h. The reaction mixture was cooled to RT and filtered through celite and the filtrate was concentrated under reduced pressure to afford 4-((6-Bromo-3-(difluoromethoxy)-2-methoxyphenoxy)methyl)benzamide as a solid (1 g, 67%).

後処理

  1. customthe resultant reaction mixture
  2. temperatureThe reaction mixture was cooled to RT
  3. filtrationfiltered through celite
  4. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-fab9fce34bd4421fb1d89343426d8482
出典データセット
uspto-grants-2015_06
特許番号
US09051290B2

反応ノート

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