1,2-Dichloroethane → 4-(Chloromethyl)-2,6-dimethylpyridine hydrochloride
反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[CH:5]=[C:4]([CH3:10])[N:3]=1.[Cl:11]CCCl.S(Cl)([Cl:17])=O>CN(C=O)C>[ClH:11].[Cl:17][CH2:8][C:6]1[CH:7]=[C:2]([CH3:1])[N:3]=[C:4]([CH3:10])[CH:5]=1参加物
5
実験手順
(2,6-Dimethylpyridin-4-yl)methanol (457 mg) was mixed with DCE (8 ml), and thionyl chloride (0.6 ml) and DMF (19 mg) were added thereto, followed by stirring at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure to obtain 4-(chloromethyl)-2,6-dimethylpyridine hydrochloride (567 mg).
後処理
- additionwere added
- concentrationThe reaction mixture was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-fdd973e5c9704b20b4c08ee03c4b50b7
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09051283B2
反応ノート
読み込み中…