Trifluoroacetic acid → 1-(Azetidin-3-yl)ethan-1-one; trifluoroacetic acid

HRID 2172108ノート

反応式

HRID 2172108 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([N:15]1[CH2:18][CH:17]([C:19](=[O:21])[CH3:20])[CH2:16]1)=O)(C)(C)C>ClCCl>[OH:5][C:3]([C:2]([F:7])([F:6])[F:1])=[O:4].[NH:15]1[CH2:18][CH:17]([C:19](=[O:21])[CH3:20])[CH2:16]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 59841137tert-Butyl 3-acetylazetidine-1-carboxylate

生成物 1

HCID 866729861-(Azetidin-3-yl)ethan-1-one; trifluoroacetic acid収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (8 mL) was added to a suspension of 3-acetyl-azetidine-1-carboxylic acid tert-butyl ester (800 mg, 4.0 mmol) in dichloromethane (20 mL). The reaction mixture was stirred at room temperature for 4 hours and concentrated to dryness to afford the title product as a colorless gum (800 mg, 100%).

後処理

  1. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-915c1394af5e4adf9318cc1879c159a0
出典データセット
uspto-grants-2015_06
特許番号
US09051321B2

反応ノート

読み込み中…