Hydrochloric Acid → HCID 178520944、化合物

cis-4-(Trifluoromethyl)cyclohexanecarboxylic acid (1.05 g, 5.4 mmol) and tetrahydrofuran (20 ml) were mixed and ice-cooled. A borane-tetrahydrofuran complex (10.71 ml, 10.7 mmol) was added to the mixture dropwise. After the completion of dropwise addition, the reaction mixture was stirred at room temperature overnight. 1 N hydrochloric acid was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with water and a saturated sodium chloride aqueous solution, dried over sodium sulfate, and concentrated to afford the title compound as a colorless oil (0.92 g, 94%).

1. temperatureice-cooled
2. additionA borane-tetrahydrofuran complex (10.71 ml, 10.7 mmol) was added to the mixture dropwise
3. additionAfter the completion of dropwise addition
4. extractionfollowed by extraction with ethyl acetate
5. washThe organic layer was washed with water
6. dry with materiala saturated sodium chloride aqueous solution, dried over sodium sulfate
7. concentrationconcentrated

ORDレコード

ord-7540266f46bb4a14b916614f67707c98

出典データセット

uspto-grants-2015_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09051333B2