A solution of 5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (Intermediate D, 0.400 g, 1.019 mmol), N-(5-fluorothiazol-2-yl)-1H-imidazole-1-sulfonamide (Intermediate N, 1.012 g, 4.07 mmol), and triethylamine (2.84 ml, 20.37 mmol) in 3 mL THF was heated to 80° C. for 30 minutes. LC/MS showed product so the reaction mixture was diluted with EtOAc and washed with 1 N citric acid. The organics were dried over MgSO4 and concentrated. Purification of the resulting residue by silica gel column chromatography (0 to 100% EtOAc/heptane) gave 5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(5-fluorothiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide (0.150 g, 0.280 mmol). 1H NMR (400 MHz, Acetone-d6) δ ppm: 8.06 (s, 1H), 7.83 (d, J=7.8 Hz, 1H), 7.51-7.57 (m, 1H), 7.24-7.35 (m, 2H), 7.08 (s, 1H), 7.05 (d, J=5.7 Hz, 1H), 4.37 (s, 2H), 3.30-3.39 (m, 2H), 2.47-2.60 (m, 2H)
