Trifluoroacetic acid → 5-Chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

HRID 2172589ノート

反応式

HRID 2172589 の反応式
[Cl:1][C:2]1[C:3](=[O:36])[N:4]([C:19]2[CH:24]=[C:23]([C:25]3[CH:30]=[CH:29][N:28]=[C:27]([C:31]([OH:34])([CH3:33])[CH3:32])[N:26]=3)[CH:22]=[CH:21][C:20]=2[CH3:35])[C:5]([CH3:18])=[N:6][C:7]=1[O:8]CC1C=CC(OC)=CC=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[C:3](=[O:36])[N:4]([C:19]2[CH:24]=[C:23]([C:25]3[CH:30]=[CH:29][N:28]=[C:27]([C:31]([OH:34])([CH3:32])[CH3:33])[N:26]=3)[CH:22]=[CH:21][C:20]=2[CH3:35])[C:5]([CH3:18])=[N:6][C:7]=1[OH:8]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 866862845-chloro-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-6-(4-methoxy-benzyloxy)-2-methyl-3H-pyrimidin-4-one

生成物 1

HCID 1363878065-Chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution 5-chloro-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-6-(4-methoxy-benzyloxy)-2-methyl-3H-pyrimidin-4-one from Step I (661 mg, 1.31 mmol) in dichloromethane (5 mL) was added trifluoroacetic acid (1 mL). The solution was stirred at ambient temperature for one hour. Concentration in vacuo provided the title compound as a yellow solid (assume theoretical yield). MS (M+H): 387

後処理

  1. concentrationConcentration in vacuo

出典と根拠

ORDレコード
ord-0ddde50e769a4f06b743f927d14a6100
出典データセット
uspto-grants-2015_06
特許番号
US09056110B2

反応ノート

読み込み中…