Methanesulfonyl chloride → HCID 86672755、化合物
反応式
[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][N:3]=1.C(N(CC)C(C)C)(C)C.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>ClCCl>[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][O:9][S:20]([CH3:19])(=[O:22])=[O:21])[CH:5]=[CH:4][N:3]=1参加物
5
実験手順
To a stirred 0° C. solution of (2-bromo-pyridin-4-yl)-methanol (3.00 g, 16.0 mmol) and N,N-diisopropylethylamine (8.3 mL, 48 mmol) in dichloromethane (30 mL) is added methanesulfonyl chloride (1.30 mL, 16.8 mmol). The resulting mixture is warmed to room temperature. After 1 hour, the mixture is diluted with dichloromethane (20 mL) and washed with saturated aqueous ammonium chloride (3×10 mL), saturated aqueous sodium bicarbonate (10 mL), brine (10 mL), dried over MgSO4, filtered and concentrated to afford crude methanesulfonic acid 2-bromo-pyridin-4-ylmethyl ester, which is used without purification.