Diisobutylaluminum hydride → 2-Fluoro-5-(1-oxopropan-2-yl)benzonitrile
反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]([CH3:15])[C:11](OC)=[O:12])[CH:6]=[CH:7][C:8]=1[F:9])#[N:2].CC(C[AlH]CC(C)C)C>C1COCC1>[F:9][C:8]1[CH:7]=[CH:6][C:5]([CH:10]([CH3:15])[CH:11]=[O:12])=[CH:4][C:3]=1[C:1]#[N:2]参加物
4
実験手順
A solution of compound methyl 2-(3-cyano-4-fluorophenyl)propanoate (50 mg, 0.24 mmol) in 5 mL of anhydrous THF was cooled to 0° C. and then added DIBAL-H (0.3 mmol) was added. The mixture was warmed to ambient temperature and stirred at ambient temperature for 1.5 hours. The reaction was quenched with water, extracte with EtOAc. The organic layer was washed with saturated chloride, dried over anhydrous sodium sulfate and concentrated. The 2-fluoro-5-(1-oxopropan-2-yl)benzonitrile was used for next step without purification.
後処理
- customThe reaction was quenched with water, extracte with EtOAc
- washThe organic layer was washed with saturated chloride
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated
- customThe 2-fluoro-5-(1-oxopropan-2-yl)benzonitrile was used for next step without purification
出典と根拠
- ORDレコード
- ord-88859a80a4bb42f8941660852d579e1d
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09056859B2
反応ノート
読み込み中…