2-Pyrazineacetic acid, 5-(hydroxyamino)-, ethyl ester → Ethyl 2-(5-aminopyrazin-2-YL)acetate

HRID 2173330ノート

反応式

HRID 2173330 の反応式
O[NH:2][C:3]1[N:4]=[CH:5][C:6]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[N:7][CH:8]=1>CO.[OH-].[OH-].[Pd+2]>[NH2:2][C:3]1[N:4]=[CH:5][C:6]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[N:7][CH:8]=1

参加物

4

反応物 1

HCID 1362782792-Pyrazineacetic acid, 5-(hydroxyamino)-, ethyl ester

生成物 1

HCID 72212710Ethyl 2-(5-aminopyrazin-2-YL)acetate

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

A mixture of ethyl [5-(hydroxyamino)pyrazin-2-yl]acetate (2.8 g, 14.2 mmol) and Pd(OH)2 (3 g, 10%) in 150 mL of methanol was stirred at room temperature under 50 psi of H2 for 2 hours before filtration. The filtrate was concentrated to afford ethyl (5-aminopyrazin-2-yl)acetate. 1H-NMR (400 MHz, CDCl3) δ ppm 7.96 (s, 1H), 7.94 (s, 1H), 4.59 (brs, 2H), 4.18 (q, J=7.2 Hz, 2H), 3.71 (s, 2H), 1.25 (t, J=7.2 Hz, 3H).

後処理

  1. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-676419d3fdd84cb5804ad0d3bdca7647
出典データセット
uspto-grants-2015_06
特許番号
US09056859B2

反応ノート

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