Ethyl orthoformate → HCID 57851246、化合物

反応式

[I:1][C:2]1[CH:3]=[C:4]([NH3+:16])[CH:5]=[C:6]([C:8](=[O:15])[NH:9][CH:10]([CH3:14])[CH2:11][O:12][CH3:13])[CH:7]=1.[N-:17]=[N+:18]=[N-:19].[Na+].[CH:21](OCC)(OCC)OCC>CC(O)=O>[I:1][C:2]1[CH:7]=[C:6]([CH:5]=[C:4]([N:16]2[CH:21]=[N:19][N:18]=[N:17]2)[CH:3]=1)[C:8]([NH:9][CH:10]([CH3:14])[CH2:11][O:12][CH3:13])=[O:15]

参加物

実験手順

To a solution of 3-Iodo-5-(2-methoxy-1-methyl-ethylcarbamoyl)-phenyl-ammonium (7.47 g, 22.4 mmol) and NaN3 (2.68 g, 41.2 mmol) in AcOH (100 mL) was added HC(OEt)3 (18.3 mL, 110 mmol) at room temperature. The reaction mixture was brought to reflux for 4 hours, then cooled to room temperature. The solvent was removed in vacuo and the residue was purified by silica-gel chromatography to give 3-Iodo-N-(2-methoxy-1-methyl-ethyl)-5-tetrazol-1-yl-benzamide as a white solid (6.30 g, 72%). MS (M+H)=388.