2-(3-fluoro-4-nitrophenyl)acetic acid → 4-Amino-3-fluorophenylacetic acid

HRID 2173385ノート

反応式

HRID 2173385 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>CCOC(C)=O.[Pd]>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([CH2:11][C:12]([OH:14])=[O:13])=[CH:3][C:2]=1[F:1]

参加物

4

反応物 1

HCID 27746652-(3-fluoro-4-nitrophenyl)acetic acid

生成物 1

HCID 27783244-Amino-3-fluorophenylacetic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of (3-fluoro-4-nitrophenyl)acetic acid (1 g, 5 mmol) in 30 mL of EtOAc was added 180 mg of Pd/C was stirred at room temperature under H2 atmosphere overnight. The reaction mixture was filtrated and concentrated to give (4-amino-3-fluorophenyl)acetic acid.

後処理

  1. filtrationThe reaction mixture was filtrated
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-cc367f5c70864bcca07db82522367cec
出典データセット
uspto-grants-2015_06
特許番号
US09056859B2

反応ノート

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