Chloroacetonitrile → HCID 117729502、化合物

HRID 2173472ノート

反応式

HRID 2173472 の反応式
[CH3:1][C:2]1[C:7]([CH3:8])=[N:6][NH:5][C:4](=[S:9])[C:3]=1[C:10]#[N:11].C([O-])(=O)C.[Na+].Cl[CH2:18][C:19]#[N:20]>C(O)C.CC(O)C>[NH2:11][C:10]1[C:3]2[C:2]([CH3:1])=[C:7]([CH3:8])[N:6]=[N:5][C:4]=2[S:9][C:18]=1[C:19]#[N:20]

参加物

6

反応物 3

HCID 7856ChloroacetonitrileHCID 517045Sodium AcetateHCID 256489772,3-Dihydro-5,6-dimethyl-3-thioxo-4-pyridazinecarbonitrile

生成物 1

HCID 117729502HCID 117729502、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3776Isopropanol溶媒

実験手順

The 5,6,-dimethyl-3-thioxo-2,3-dihydropyridazine-4-carbonitrile (99 mg, 0.60 mmol) was stirred in ethanol (6.0 mL). Sodium acetate (50 mg, 0.60 mmol) and chloroacetonitrile (0.040 mL, 0.60 mmol) were added and the mixture was stirred at ambient temperature for 90 minutes. The mixture was then diluted with IPA, stirred for 15 minutes, and filtered. The solute was concentrated in vacuo, and the resulting solid was dried overnight at 60° C. in a vacuum oven to give the product. LC/MS: RT=0.38 min., m/z=205 [M+H]+.

後処理

  1. stirringstirred for 15 minutes
  2. filtrationfiltered
  3. concentrationThe solute was concentrated in vacuo
  4. customthe resulting solid was dried overnight at 60° C. in a vacuum oven
  5. customto give the product

出典と根拠

ORDレコード
ord-bcb2fbd5ca604b6381446071b81a4b68
出典データセット
uspto-grants-2015_06
特許番号
US09056875B2

反応ノート

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